A novel potentiometric multisensor system was developed for the simultaneous determination of chloride, potassium, sodium, and calcium ions in human body fluids. The device consists of an integrated platform comprising four ion-selective paste electrodes with renewable sensing surfaces, enabling repeated use and stable performance. Conditioning, calibration, and analysis were performed in mixed solutions containing all target ions, allowing simultaneous determination of calibration curves and significantly reducing analysis time. The multisensor exhibited near-Nernstian slopes, wide linear concentration ranges, high capacitance, and low potential drift, ensuring reliable operation within the physiological pH range. The system was successfully applied to diluted samples of artificial saliva, sweat, and blood serum of biological origin, yielding recovery values between 97% and 108%, thus confirming its accuracy and practical applicability. This work presents an efficient potentiometric platform for simultaneous electrolyte monitoring in complex biological matrices.
Niemiec et al. (Fri,) studied this question.
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