What question did this study set out to answer?

This research aims to identify predictors of VRE infection in liver transplant recipients, focusing on colonization scores.

March 8, 2026

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

Key Points

This research aims to identify predictors of VRE infection in liver transplant recipients, focusing on colonization scores.
Analysis of data from 1209 liver transplant recipients
Assessment of postoperative VRE colonization and other risk factors
Utilization of statistical modeling to determine predictors of infection
6.3% of liver transplant recipients developed VRE infection, mainly intra-abdominal
Time-updated colonization score emerged as the strongest predictor (HR 7.59)
Intraoperative bleeding and early re-transplantation also significantly increased infection risk
Certain factors, like viral hepatitis and lower comorbidity index, were linked to a reduced risk of infection

Abstract

Among 1209 LT recipients, 76 (6.3%) developed VRE infection, most commonly intra-abdominal (58.4%). Time-updated post-LT VRE colonization was the strongest predictor (HR 7.59). Additional risk factors included intraoperative bleeding (HR 4.06), early re-transplantation (HR 3.85), pre-LT VRE colonization (HR 3.20), renal replacement therapy (HR 2.01), and intensive care unit length of stay (HR 1.01/day). Viral hepatitis (HR 0.55), autoimmune hepatitis (HR 0.34), higher Charlson Comorbidity Index (HR 0.84), and deceased donors (HR 0.24) were associated with a lower risk of VRE infection. The final model showed good discrimination (AUROC = 0.76-0.85) with balanced sensitivity (75%-93%) and specificity (75%-86%).

Predicting VRE Infection After Liver Transplantation With a Time-Updated Colonization Score.

Key Points

Abstract

Cite This Study