A Modular Computational Approach for Assessing Active and Passive Force Contributions in Interstitial Lymphatic Fluid Uptake

Key Points

• The aim is to evaluate how both active and passive forces affect fluid uptake in lymphatic systems.
• Developed a computational framework to analyze lymphatic drainage mechanics.
• Assessed the effects of branching topology on fluid dynamics.
• Examined the role of material properties in influencing fluid flow.
• Active pumping significantly affects lymphatic drainage in branched structures.
• Passive flow is primarily influenced by interstitial properties.
• Quantitative differences were observed in normal versus pathological conditions.