Resolving the mRNA Encapsulation-Release Trade-off Overcoming the inherent trade-off between mRNA encapsulation and intracellular release remains a central challenge for lipid nanoparticles. Yufei Xia, Ying Ren, and co-workers rationally engineer compensatory forces in LNP (DOI: 10.1002/adma.202512235). By leveraging short-range intermolecular interactions to dynamically balance long-range Coulombic binding, reduces empty particles and ionizable lipid content, enabling efficient mRNA encapsulation and enhanced delivery for vaccination and gene-editing applications.
Gao et al. (Sun,) studied this question.