What question did this study set out to answer?

This research aims to compare the performance of ICBD, ISG, and PEDBD classification criteria in pediatric Behçet’s disease and assess long-term damage.

March 12, 2026Open Access

Clinical phenotype and long-term damage in paediatric Behçet’s disease: comparative performance of ISG, ICBD and PEDBD classification criteria in a retrospective endemic cohort

Key Points

This research aims to compare the performance of ICBD, ISG, and PEDBD classification criteria in pediatric Behçet’s disease and assess long-term damage.
Retrospective analysis of a cohort with pediatric Behçet’s disease
Comparison of classification criteria: ICBD, ISG, and PEDBD
Assessment of morbidity related to neurovascular events and ocular disease
ICBD showed superior sensitivity compared to ISG and PEDBD
ISG and PEDBD classified only 50% of cases
Morbidity associated mainly with neurovascular events, less frequently with ocular disease

Abstract

In this endemic paediatric cohort, ICBD demonstrated superior sensitivity, while ISG and PEDBD classified only half of cases. Morbidity was driven by neurovascular events and, less frequently, posterior-segment ocular disease. Findings support an ICBD-anchored approach with co-reporting of ISG/PEDBD for comparability. Low-threshold neuro-ophthalmic evaluation and timely steroid-sparing escalation are critical for sight/central nervous system-threatening disease. Targeted vascular imaging and adherence-focused adolescent care remain priorities.

Bookmark

View Full Paper

Cite This Study

Yücel et al. (Thu,) studied this question.

synapsesocial.com/papers/69b2581996eeacc4fcec7604 https://doi.org/https://doi.org/10.1136/rmdopen-2025-006514

Bookmark

View Full Paper