This study demonstrates that the combination of Res and ALA-PDT enhances the inhibition of glioblastoma cell growth compared to the single treatments. The combined therapy can induce apoptosis and autophagy in GBM cells by suppressing the ERK1/2 and mTOR signaling pathways, providing a potential new treatment for GBM. However, in vivo validation and clinical trials are essential for fully evaluating the potential of this mechanism regarding translation into clinical application.
Zhang et al. (Mon,) studied this question.