Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1 ‐mediated macrophage polarization via the PI3K /Akt pathway | Synapse
March 12, 2026Open Access
Methylophiopogonanone a attenuates pulmonary fibrosis by inhibiting SPP1 ‐mediated macrophage polarization via the PI3K /Akt pathway
Key Points
The research aims to explore the effects of methylophiopogonanone A on pulmonary fibrosis through its involvement in macrophage polarization and associated pathways.
Identified the effects of methylophiopogonanone A on pulmonary fibrosis.
Analyzed the role of SPP1 in macrophage polarization.
Examined the PI3K/Akt signaling pathway's involvement.
Methylophiopogonanone A significantly reduced pulmonary fibrosis.
Inhibition of SPP1 led to decreased macrophage polarization.
Activation of the PI3K/Akt pathway was linked to these effects.
Abstract
This study identifies that MOA is a promising natural compound that alleviates pulmonary fibrosis by inhibiting SPP1-mediated macrophage polarization via the PI3K/Akt pathway.