March 28, 2018

PCSK9 regulates expression of scavenger receptors and ox-LDL uptake in macrophages

Key Points

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Abstract

This study shows that in an inflammatory milieu, elevated levels of PCSK9 potently stimulate the expression of SRs (principally LOX-1) and ox-LDL uptake in macrophages, and thus contribute to the process of atherogenesis.

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Cite This Study

Ding et al. (Wed,) studied this question.

synapsesocial.com/papers/69b31ef1033832e42976e18e https://doi.org/https://doi.org/10.1093/cvr/cvy079

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