Background: Chronic kidney disease (CKD) is commonly associated with peripheral neuropathy, yet its pathophysiology remains incompletely understood. Inflammatory markers, particularly interleukin-6 (IL-6) and C-reactive protein (CRP), are thought to play a role in the development and persistence of neuropathic pain. This study aimed to evaluate the relationship between neuropathic pain and serum IL-6 and CRP levels in patients with stage 3–5 CKD.Methods: This prospective single-center study included 80 patients: 40 with stage 3–4 CKD and 40 with stage 5 CKD on dialysis (5D). Neuropathic pain was assessed using the PainDETECT questionnaire. Serum IL-6 and CRP levels were measured, and their associations with neuropathic pain were analyzed using correlation analysis, ROC curves, and multivariate logistic regression.Results: Neuropathic pain was present in 44% of stage 3–4 and 73% of stage 5D patients. PainDETECT scores were significantly higher in stage 5D (p=0.009) and showed moderate positive correlations with IL-6 (r=0.642, p
Kiracı et al. (Tue,) studied this question.