What question did this study set out to answer?

To establish the H-NED framework as a theoretical model of quantum consciousness related to neurodegenerative diseases.

March 13, 2026Open Access

The H-NED Framework: Hermitian Hardware - The Quantum Consciousness Substrate (From Ice XI Ferroelectric Ordering to Ricci Flow Plasticity)

Key Points

To establish the H-NED framework as a theoretical model of quantum consciousness related to neurodegenerative diseases.
Developed a Hermitian infrastructure framework integrating neurology and quantum mechanics.
Analyzed interfacial water phase transition in microtubules at physiological temperatures.
Calculated effective critical temperature and applied non-equilibrium thermodynamics principles.
Identified a critical temperature for water phase transitions within microtubules.
Introduced the topological invariant for stability in neuro-glial systems.
Mapped Ricci flow to synaptic plasticity, providing insights into learning mechanisms.

Abstract

We establish the complete Hermitian infrastructure of the H-NED (Hydrodynamic Neuro-glial Electro-Dynamics) framework. This theoretical model demonstrates that interfacial water confined within microtubule (MT) lumens (d ≈ 15 nm) undergoes a field-induced ferroelectric phase transition from frustrated hexagonal ice (Ice Ih, space group P6₃/mmc, residual entropy S₀ = R ln (3/2) ) to ordered orthorhombic ice (Ice XI, space group Cmc2₁, S₀ = 0) at physiological temperature (Tbody = 310 K). We calculate and define the effective critical temperature Tcᵉff = 312 K. The system's dynamics are articulated through a comprehensive, quantified Hamiltonian ĤH-NED = Σ i=1 to 6 Ĥᵢ, integrating non-equilibrium thermodynamics and thermal coherence (Thermo Field Dynamics). Furthermore, we introduce the topological invariant INED = Σ i=1 to N Qₜop^ (i) ∈ ℤ ensuring homotopy protection, the Lorello-Davydov Solitons (ΨLD) for energy transduction, and the Einstein-Lorello equation mapping Ricci flow to synaptic plasticity and learning via Quantum Durotaxis. This foundational manuscript, supported by extensive mathematical proofs in the Supplementary Information, establishes a rigorous physical substrate for resolving clinical pathology mechanisms in neurodegenerative diseases (MS, Alzheimer's).

The H-NED Framework: Hermitian Hardware - The Quantum Consciousness Substrate (From Ice XI Ferroelectric Ordering to Ricci Flow Plasticity)

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