Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity

Key Points

• This research aims to synthesize sulfanyl derivatives of 1,2,4-triazoles and assess their cytotoxic properties.
• Synthesis via Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones
• Evaluation of the structural characteristics of the synthesized compounds
• Assessment of cytotoxicity in vitro.
• Sulfanyl derivatives of 1,2,4-triazoles were successfully synthesized
• The evaluation revealed varying levels of cytotoxicity against cancer cells.