What question did this study set out to answer?

To assess the clinical and immunovirological status of children and young adults with early-life-acquired HIV and identify factors influencing outcomes.

March 13, 2026Open Access

Clinical and immunovirological status in children, adolescents and young adults with early-life-acquired HIV: a Spanish multi-cohort analysis since 2020

Key Points

To assess the clinical and immunovirological status of children and young adults with early-life-acquired HIV and identify factors influencing outcomes.
Multi-cohort analysis focusing on early-life-acquired HIV cases since 2020
Evaluation of ART regimens and their effects on viral failure
Assessment of adherence levels and immune recovery rates in adolescents and young adults
PI-based regimens are linked to higher rates of viral failure
Integrase strand transfer inhibitors show protective effects
Targeted support improves adherence and immune recovery in adolescents and young adults

Abstract

Early ART initiation and tailored interventions are essential to optimize outcomes in ELHIV populations. PI-based regimens were a risk factor for VF, whereas integrase strand transfer inhibitors appeared protective. Adolescents and young adults require targeted support to improve adherence and immune recovery, aligning with UNAIDS goals.

Read Full Paperexternally

Bookmark

View Full Paper

Cite This Study

Tarancon-Diez et al. (Thu,) studied this question.

synapsesocial.com/papers/69b3ac2b02a1e69014ccda8c https://doi.org/https://doi.org/10.1093/jac/dkag079

Bookmark

View Full Paper