Exosomal Lnc-DLK1-35 reprograms microglia into a pro-tumorigenic phenotype via a non-canonical cytokine signature to promote glioblastoma progression and chemoresistance.

Key Points

• The aim is to investigate how exosomal lnc-dlk1-35 influences microglia and contributes to glioblastoma progression and chemoresistance.
• Cultured microglia cells were treated with exosomal lnc-dlk1-35 for reprogramming.
• Cytokine profiles were analyzed to identify non-canonical signatures.
• Invasion and TMZ resistance assays were conducted to assess functional outcomes.
• Exosomal lnc-dlk1-35 effectively transformed microglia into a pro-tumorigenic phenotype.
• A unique non-canonical cytokine signature was identified in the reprogrammed microglia.
• Targeting this signaling pathway disrupted microglia-GBM interactions, indicating potential for therapeutic intervention.