What does this research mean for the field?

Hungry bone syndrome occurs frequently after parathyroidectomy in patients with secondary and tertiary hyperparathyroidism. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

This study examines the occurrence of hungry bone syndrome following parathyroidectomy in patients with secondary and tertiary hyperparathyroidism.

March 14, 2026Open Access

Hungry bone syndrome after parathyroidectomy in secondary and tertiary hyperparathyroidism: a retrospective cohort study

Key Points

This study examines the occurrence of hungry bone syndrome following parathyroidectomy in patients with secondary and tertiary hyperparathyroidism.
Conducted a retrospective cohort study
Included patients with secondary and tertiary hyperparathyroidism
Analyzed post-surgical complications related to bone metabolism
Documented cases of hungry bone syndrome after parathyroidectomy
Increased fracture risk noted in post-operative patients
Highlighted the importance of monitoring calcium levels post-surgery

Abstract

Hyperparathyroidism (HPT) is a condition characterized by excessive secretion of parathyroid hormone (PTH), leading to disturbances in calcium (Ca) and phosphorus (P) metabolism 1.Secondary HPT (SHPT) and tertiary HPT (THPT) commonly develop in patients with chronic kidney disease, particularly those undergoing long-term dialysis 2,3.In these patients, chronic elevations in PTH drive high bone turnover, leading to compromised bone quality and an increased risk of fractures.If left untreated, HPT can contribute to severe bone disease, vascular calcifications, and cardiovascular complications 1,4.Parathyroidectomy (PTX) is the definitive treatment for refractory SHPT and THPT, particularly when medical management fails 5,6.Surgical approaches include subtotal PTX (SubPTX) and total PTX with or without

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