Characterisation of the Novel HLA‐DQB1*03:03:37 Allele by Next Generation Sequencing

Key Points

• The aim is to characterise the novel HLA-DQB1*03:03:37 allele and compare it to a related allele.
• Used next generation sequencing to analyse the allele structure.
• Compared the nucleotide sequences of HLA-DQB1*03:03:37 and HLA-DQB1*03:03:02:02.
• Identified differences at specific positions in the genetic code.
• The HLA-DQB1*03:03:37 allele has a synonymous nucleotide difference at position 5745.
• No significant structural variations were found outside the identified difference.