Use of Oral Metformin Therapy for Therapy‐Induced Hyperglycemia in Pediatric Patients With Acute Lymphoblastic Leukemia

Key Points

• To evaluate the efficacy and safety of oral metformin therapy for managing TIH in pediatric patients with ALL.
• Pediatric patients with acute lymphoblastic leukemia were treated with oral metformin.
• The study assessed the incidence of non-severe hyperglycemia and insulin therapy reliance during treatment phases.
• 73.4% of patients could avoid insulin therapy during induction.
• 68.1% of patients could avoid insulin therapy during re-induction.