What question did this study set out to answer?

This research aims to explore how folate influences colorectal cancer and the immune system's response.

March 16, 2026Open Access

Folate promotes colorectal cancer progression by impairing CD8+ T cell function and recruitment via SLC19A1/p-AKT/NOTCH1 axis and CCL5 downregulation

Key Points

This research aims to explore how folate influences colorectal cancer and the immune system's response.
Conducted preclinical experiments using mouse models to assess immune functions.
Analyzed CD8+ T cell recruitment and activity in relation to folate levels.
Investigated molecular pathways including SLC19A1, AKT, NOTCH1, and CCL5.
Folate exposure was linked to reduced recruitment of CD8+ T cells.
Impairments in anti-tumor activity of CD8+ T cells were observed in treated mice.
The SLC19A1/p-AKT/NOTCH1 pathway was implicated in the observed effects.

Abstract

This preclinical study suggests that folate may facilitate CRC progression and immune evasion by impairing CD8+ T cell recruitment and anti-tumor activity. These findings represent a proof-of-concept in mouse immunometabolism offering insights into potential mechanisms underlying folate-driven CRC progression and immune suppression. Broader implications for nutritional interventions or immunotherapy in patients remain speculative at this preclinical stage and would require further clinical investigation.

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Cite This Study

Qing et al. (Fri,) studied this question.

synapsesocial.com/papers/69b79da78166e15b153aae1e https://doi.org/https://doi.org/10.1186/s12967-026-07993-7

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