From ‘senile dementia’ to non-vascular Alzheimer’s synucleinopathy: the evolution of dementia classification | Synapse
March 18, 2026
From ‘senile dementia’ to non-vascular Alzheimer’s synucleinopathy: the evolution of dementia classification
Key Points
To discuss the evolution of dementia classifications, particularly the shift towards biological classifications.
Analysis of literature on dementia classification.
Reference to Mastenbroek et al.'s findings.
Discussion of historical and current classifications of dementia.
Recognition of biological factors in dementia categorization.
Emphasis on non-vascular Alzheimer’s synucleinopathy.
Shift in understanding the underlying mechanisms of dementia.
Abstract
This scientific commentary refers to ‘Biological classification of memory clinic patients’ by Mastenbroek et al. (https://doi.org/10.1093/brain/awaf411).