ABSTRACT Two previously undescribed sesquiterpenoid‐benzaldehyde hybrids, aquisinoids A ( 1 ) and B ( 2 ), were isolated from agarwood of Aquilaria sinensis . Their structures were elucidated by comprehensive spectroscopic data analysis, single‐crystal x‐ray diffraction, and electronic circular dichroism calculations. Structurally, both compounds feature a polycyclic core formed by connecting a prezizaane‐type sesquiterpenoid unit with a p ‐hydroxybenzaldehyde moiety via a 1,3‐dioxolane bridge. Compounds 1 and 2 exhibited moderate inhibition on nitric oxide (NO) production in lipopolysaccharide (LPS)‐induced RAW 264.7 macrophages, with IC 50 values of 22.4 and 26.7 µM, respectively.
Ma et al. (Sun,) studied this question.