Novel Pediatric Aggressive Adipose Tumor With Pathogenic TERT Promoter Variant and an Initial Durable Response to Vincristine and Dactinomycin | Synapse
March 18, 2026
Novel Pediatric Aggressive Adipose Tumor With Pathogenic TERT Promoter Variant and an Initial Durable Response to Vincristine and Dactinomycin
Key Points
This research aims to explore a new aggressive adipose tumor in pediatric patients with a specific TERT promoter variant and treatment response.
Identification of a novel pediatric adipose tumor
Analysis of TERT promoter variant
Evaluation of treatment response to vincristine and dactinomycin
The tumor displayed a pathogenic TERT promoter variant
There was an initial durable response to vincristine and dactinomycin
This suggests potential effectiveness of these therapies in similar cases.