Cortical synchronization of spontaneous trigeminal neuropathic pain monitored with in vivo optical imaging of calcium activity in freely moving mice
Key Points
This research aims to develop a method for monitoring cortical activity related to trigeminal neuropathic pain in mice.
Used in vivo optical imaging to monitor calcium activity in the cortex of freely moving mice
Analyzed synchronization of cortical ensemble activity
Evaluated the synchronization index as a potential measure of pain-like behavior
Demonstrated effective monitoring of synchronized cortical activity during spontaneous pain behavior
Established a relationship between synchronization index and neuropathic pain-like behavior
Abstract
Our findings provided a method of monitoring the synchronized activity of cortical ensemble in freely moving animals. Synchronization index may be used to decode spontaneous neuropathic pain-like behavior.
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Cortical synchronization of spontaneous trigeminal neuropathic pain monitored with in vivo optical imaging of calcium activity in freely moving mice | Synapse