Clinical Pharmacist Interventions in a Brazilian Intensive Care Unit: An Eight‐Year Retrospective Analysis

Objective To identify the pharmaceutical interventions carried out by the clinical pharmacy service in an adult intensive care unit and to evaluate their evolution over an 8‐year period. Methods This descriptive study evaluated pharmaceutical interventions recorded between 2016 and 2023 in a general adult ICU of a public hospital in Brasília, Brazil. Data were collected from a clinical pharmacy database, including patient demographics, intervention types, acceptance rates, targeted professionals, and medications involved. Interventions were categorized and analyzed by age groups, year, and professional target. Results A total of 3582 interventions were performed in 663 patients, with an acceptance rate of 96%. The median patient age was 58 years, and 56.9% were male. The most frequent interventions were medication addition (23.5%), discontinuation (10.5%), and dosage increase (8.2%). Interventions predominantly targeted the medical team, with a shift from nursing staff in the service’s initial year. The main medications were antimicrobials (notably meropenem), anticoagulants (enoxaparin), and proton pump inhibitors (pantoprazole, omeprazole). Over time, a qualitative and quantitative change in intervention profiles was observed, with increased pharmacist participation in pharmacotherapy decisions. Conclusion Pharmaceutical interventions in the ICU evolved towards greater involvement in pharmacotherapy management, predominantly directed at medical professionals. High acceptance rates indicate the integration of pharmacists into the multidisciplinary team. Further studies are recommended to explore the reduction in nursing‐directed interventions and the impact on patient outcomes.