What question did this study set out to answer?

To explore the role of CRBN in regulating fibrosis following glaucoma drainage surgery and evaluate the effects of thalidomide.

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March 22, 2026Open Access

Targeting CRBN With Thalidomide Suppresses Fibrosis After Glaucoma Drainage Surgery Through NF-κB Pathway Inhibition

Key Points

To explore the role of CRBN in regulating fibrosis following glaucoma drainage surgery and evaluate the effects of thalidomide.
Investigated the effects of thalidomide on CRBN activity
Analyzed the inhibition of the NF-κB pathway
Assessed anti-fibrotic outcomes post-glaucoma drainage surgery
Thalidomide effectively targets CRBN
Reduced fibrosis observed following treatment
Inhibition of the NF-κB pathway is linked to observed anti-fibrotic effects

Abstract

CRBN is a key protein regulating fibrosis following GDS. THD exerts anti-fibrotic effects by targeting CRBN and inhibiting the NF-κB pathway. These findings unveil a novel intervention target, CRBN, for attenuating fibrogenesis after GDS.

Targeting CRBN With Thalidomide Suppresses Fibrosis After Glaucoma Drainage Surgery Through NF-κB Pathway Inhibition

Key Points

Abstract

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