Weight change across adulthood in relation to ultrasound-defined metabolic dysfunction-associated steatotic liver disease: a population-based study

Key Points

• To examine the relationship between weight change during adulthood and the risk of metabolic dysfunction-associated steatotic liver disease (MASLD).
• Analyzed population-based data on weight changes across adulthood.
• Assessed the impact of obesity and weight gain on MASLD risk.
• Identified severe obesity as a key risk factor.
• Long-term obesity and weight gain during early adulthood significantly elevate MASLD risk.
• Sustained obesity and progression to obesity were major contributing factors.
• Severe obesity showed the strongest association with increased MASLD risk.