What question did this study set out to answer?

To evaluate long-term outcomes of endoscopic submucosal dissection (ESD) for T1 colorectal cancer (CRC).

March 23, 2026Open Access

Long-term Outcomes after Endoscopic Submucosal Dissection for T1 Colorectal Cancer: A Multicenter Prospective Study

Key Points

To evaluate long-term outcomes of endoscopic submucosal dissection (ESD) for T1 colorectal cancer (CRC).
Conducted a multicenter prospective study
Assessed patients with low-risk and high-risk T1 CRC
Monitored for recurrence and disease-specific mortality
No recurrence or disease-specific mortality in low-risk T1 CRC patients
High-risk T1 CRC may require additional surgery to prevent local recurrence
Uncertainty remains about the impact of surgery on distant metastasis and disease-specific survival (DSS)

Abstract

ESD alone appears appropriate for low-risk T1 CRC, with no recurrence or disease-specific mortality observed, suggesting that intensive surveillance is unnecessary after curative ESD. In high-risk T1 CRC, additional surgery could prevent local recurrence; however, its impact on distant metastasis and DSS remains unclear.

Long-term Outcomes after Endoscopic Submucosal Dissection for T1 Colorectal Cancer: A Multicenter Prospective Study

Key Points

Abstract

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