A Novel Engineered Skin Closes Full Thickness Burn Wounds: A Case Report

This report describes initial use of a novel bioengineered bilaminar skin substitute to obtain healing in a 6-year-old child with 63% total body surface area (TBSA) full thickness burns.This platelet gel-based Human Skin Equivalent (PG-HSE) autograft differs from other second generation bilaminar biologic skin substitutes, incorporating a platelet -derived hydrogel scaffold.A 5 cm 2 skin biopsy was used to manufacture 500 cm 2 of bilaminar skin.This was applied to an excised wound bed treated with a biodegradable dermal skin substitute, NovoSorb Biodegradable Temporising Matrix (BTM) (PolyNovo Biomaterials Pty Ltd, Port Melbourne, Victoria, Australia).The take rate of the grafted PG-HSE was 95% at 2 weeks post grafting, with no wound breakdown or requirement for further surgery at the PG-HSE graft sites at 15 months post grafting.This case demonstrates the efficacy of this bioengineered skin autograft in closing temporised full-thickness burns.