Practical and robust access to enimides via DMAPO-catalyzed coupling of carboxylic acids with secondary enamides | Synapse
March 26, 2026
Practical and robust access to enimides via DMAPO-catalyzed coupling of carboxylic acids with secondary enamides
Key Points
The aim is to develop a robust method for synthesizing α-aryl N-vinylimides using carboxylic acids as acyl sources.
Developed a protocol for the reaction of carboxylic acids with N-vinylamides.
Utilized DMAPO as a catalyst for the reaction.
Examined a range of N-vinylamide substrates for reactivity with carboxylic acids.
Successfully synthesized a variety of N-vinylimides.
Showed efficient couplings with various carboxylic acids.
Achieved improved product yields compared to traditional methods.
Abstract
Herein, a new protocol for the preparation of α-aryl N-vinylimides has been successfully developed. With carboxylic acids as the acyl source, a range of N-vinylamide could react with carboxylic acids...