Elevated Triglyceride-glucose (TyG) index levels were associated with a 30% higher 1-year mortality risk (HR 1.30) compared to the lowest tertile in critically ill patients with CKM stage 4.
Cohort (n=3,125)
No
Does a higher Triglyceride-glucose (TyG) index predict increased mortality in critically ill patients with CKM stage 4?
Higher TyG levels are independently associated with increased short- and long-term mortality in critically ill patients with CKM stage 4, suggesting its potential utility for early risk stratification.
Effect estimate: HR 1.30 (95% CI 1.08-1.55)
Absolute Event Rate: 38.68% vs 28.79%
p-value: p=<0.0001
The triglyceride–glucose (TyG) index is a well-established surrogate marker of insulin resistance (IR). Previous studies have linked higher TyG levels to an increased risk of cardiovascular events in individuals with early-stage (0–3) Cardiovascular–Kidney–Metabolic Syndrome (CKM). However, its prognostic value in critically ill patients with CKM stage 4 remains unclear. In this retrospective study, we analyzed clinical data from critically ill CKM stage 4 patients in the MIMIC-IV database. The TyG index was calculated and patients were categorized into tertiles. Cox proportional hazards models and restricted cubic spline (RCS) analyses were used to evaluate the association between the TyG index and all-cause mortality. A total of 3,125 patients were included, of whom 65.22% were male.= The 1-year all-cause mortality was 34.18% overall (28.79% in Q1, 35.06% in Q2, and 38.68% in Q3; P 0.05). These findings indicate that higher TyG levels are independently associated with increased short- and long-term mortality in critically ill patients with CKM stage 4. The TyG index may provide a simple indicator of acute metabolic disturbances and could support early risk stratification in this population. However, its role in clinical decision-making and potential utility in guiding interventions require confirmation in prospective studies.
Yin et al. (Tue,) conducted a cohort in Cardiovascular-kidney-metabolic (CKM) syndrome stage 4 (n=3,125). High Triglyceride-glucose (TyG) index (Tertile 3) vs. Low Triglyceride-glucose (TyG) index (Tertile 1) was evaluated on 365-day all-cause mortality (HR 1.30, 95% CI 1.08-1.55, p=<0.0001). Elevated Triglyceride-glucose (TyG) index levels were associated with a 30% higher 1-year mortality risk (HR 1.30) compared to the lowest tertile in critically ill patients with CKM stage 4.