What question did this study set out to answer?

To evaluate the protective effects of olive leaf extract on renal ischemia/reperfusion injury in rats.

March 26, 2026Open Access

Protective Effect of Olive Leaf Extract on Renal Ischemia/Reperfusion Injury in Rats

Key Points

To evaluate the protective effects of olive leaf extract on renal ischemia/reperfusion injury in rats.
Used male Wistar albino rats divided into four groups: Sham, Control I/R, I/R+OLE200, and I/R+OLE400.
Administered two different doses of olive leaf extract to assess dose-dependent effects.
Evaluated serum biochemical parameters and renal tissue histopathology.
OLE significantly improved serum biochemical parameters related to kidney function.
Reduced levels of pro-inflammatory cytokines such as TNF-α, IL-1β, and IL-6.
Increased total antioxidant status and decreased total oxidant status compared to the I/R control group.

Abstract

Aim: Renal ischaemia/reperfusion (I/R) injury, which is an important contributing factor to acute kidney damage, leading to increased morbidity and mortality. Olive leaf extract (OLE) possesses antioxidant and anti-inflammatory properties due to its rich polyphenolic content. This study comprehensively investigates the protective effects of OLE obtained from the Memecik variety of olive leaves against renal I/R injury, evaluated by employing two different doses.Material and Methods: A total of 32 male Wistar albino rats were randomly divided into four groups: Sham, Control I/R, I/R+OLE200, and I/R+OLE400. Serum biochemical parameters (urea, creatinine, electrolytes, total antioxidant status TAS, total oxidant status TOS, TNF-α, IL-1β, IL-6, and nitric oxide NO) and renal tissue histopathology were evaluated.Results: OLE significantly improved serum biochemical parameters, reduced pro-inflammatory cytokines, and enhanced systemic antioxidant capacity, indicated by increased TAS and decreased TOS levels compared to the I/R control group (p

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