Systemic bismuth absorption and safety of the gastric mucosal protective bismuth potassium citrate, administered as granules and tablets in healthy Chinese and validation of a new, ICP-MS bismuth assay

Key Points

• The study aims to compare the systemic absorption and safety of bismuth potassium citrate granules and tablets.
• Compared bioavailability of bismuth from granules versus tablets.
• Assessed systemic absorption of bismuth metal from both formulations.
• Conducted safety evaluations for both forms in healthy individuals.
• Granules showed superior bioavailability compared to tablets.
• Systemic absorption of bismuth metal was similar for both formulations.
• No significant safety differences were observed between granules and tablets.