factors, and outcomes of PTDM among renal transplant recipients over a ten-year period at a tertiary-care center.Methods: This retrospective observational study analyzed 184 renal transplant recipients who underwent transplantation between January 2013 and December 2023 at Kasturba Medical College, Manipal.PTDM was diagnosed in accordance with the 2014 International Consensus Guidelines.Demographic, clinical, and biochemical parameters were extracted from hospital records.Post-transplant infections, cytomegalovirus (CMV) status, graft function, and mortality were compared between patients with and without PTDM.Univariate and multivariate logistic regression analyses identified independent predictors of PTDM.Results: PTDM occurred in 32.6 % of recipients (n = 60).Mean age was similar between PTDM and non-PTDM groups (31.5 9.25 years vs. 36.6 10.08 years; p = 0.39), with male predominance in both (81.7 % vs. 81 %).Post-transplant infections were significantly higher in PTDM patients (48.3 % vs. 31.4%; p = 0.01), as was CMV infection (13.3 % vs. 6.45 %; p = 0.03).On multivariate analysis, CMV infection remained an independent predictor of PTDM (Odds Ratio 4.52, 95 % CI 1.32-15.49;p = 0.01).Graft outcomes, including serum creatinine (p = 0.82) and eGFR (p = 0.16) at one year, did not differ significantly.Mortality rates were comparable between groups (p = 0.51).Conclusion: PTDM developed in approximately one-third of kidney transplant recipients.CMV infection emerged as a significant independent risk factor, and PTDM was associated with higher posttransplant infection rates.Despite these complications, short-term graft function and mortality were unaffected.Early detection and management of modifiable risks, particularly CMV infection, are crucial to improving metabolic and transplant outcomes in this population I have no potential conflict of interest to disclose.I used generative AI and AI-assisted technologies in the writing process.
Yan et al. (Wed,) studied this question.