Table 1.(Continued) Study characteristics (n=57) Study characteristics Value Type of transplant, n (%) Kidney transplant alone 28 (49) Solid organ transplants including kidney, heart, lung, liver intestine and combined multiple transplants 36 (63) Solid organ transplants and others (haemopoietic stem cell transplants, immunosuppressed patients including haematological malignancies and solid tumours) 3 (5) Interventions*, n (%) Immunosuppressive therapy modification alone 14 (25) Nitazoxanide alone 6 (11) Intravenous immunoglobulin therapy alone 3 (5) Oral immunoglobulin therapy alone n 9 (16) Combination of treatments 17 (30) Faecal microbiota transplant 2 (4) Supportive management 4 (7) Others 5 (9) Reported outcomes, n (%) Improvement in GI symptoms 38 (67)Improvement of extra-GI symptoms 2 (4)Reporting of graft-related outcomes (stable function/rejection) 8 ( 14)Evidence of eradication of norovirus in stool 3 ( 5)No/minimal improvement in symptoms 13 ( 23)Reporting of adverse drug reactions 1 (2)* One study was conducted with multiple treatment arms.Figure 1 and 2 included as follows.Conclusion: A wide range of interventions has been used to manage norovirus infections in SOT recipients; however, the evidence is limited to observational studies, and the findings are uncertain.Highquality RCTs are needed to establish treatment efficacy and safety.I have no potential conflict of interest to disclose.I did not use generative AI and AI-assisted technologies in the writing process.
Mortari et al. (Wed,) studied this question.