What question did this study set out to answer?

To evaluate the prevalence and implications of thyroid dysfunction in patients with primary nephrotic syndrome.

March 28, 2026

Evaluation of thyroid dysfunction in patients with primary nephrotic syndrome: A single-center retrospective cohort study

LLLongzhu Li MWMeijun Wu XYXin YangPanzhihua University

Key Points

To evaluate the prevalence and implications of thyroid dysfunction in patients with primary nephrotic syndrome.
Conducted a retrospective cohort study at a single center.
Assessed thyroid function and antibody levels in nephrotic syndrome patients.
Analyzed the relationship between thyroid dysfunction, proteinuria, and hypoalbuminemia.
Thyroid dysfunction was prevalent among patients with primary nephrotic syndrome.
Higher levels of TSH and proteinuria were found in antibody-positive patients.
No association was found between thyroid autoimmunity and specific pathological types.

Abstract

Thyroid dysfunction is common in PNS and is associated with more severe proteinuria and hypoalbuminemia, though not with specific pathological types. Thyroid autoimmunity was not an independent predictor; however, antibody-positive patients had significantly higher TSH and proteinuria levels. Routine thyroid function and antibody screening are recommended for early intervention in PNS patients.

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