What question did this study set out to answer?

To highlight the severe bleeding risk associated with acquired factor V inhibitors in patients on triple antithrombotic therapy.

March 28, 2026Open Access

Acquired factor V inhibitor masked by triple antithrombotic therapy presenting as severe gastrointestinal bleeding: a case report

Key Points

To highlight the severe bleeding risk associated with acquired factor V inhibitors in patients on triple antithrombotic therapy.
Detailed case report of a 77-year-old male
Analysis of laboratory findings for coagulation parameters
Implementation of immunosuppressive therapy and CRRT for management
Patient presented with severe gastrointestinal bleeding
Acquired factor V deficiency identified due to factor V inhibitors
Successful treatment including transfusions and CRRT led to symptom resolution

Abstract

We report the case of a 77-year-old male with a history of coronary artery disease, on long-term dual antiplatelet therapy (DAPT) and edoxaban anticoagulation, who presented with severe gastrointestinal bleeding. Laboratory investigations revealed a profound acquired factor V deficiency due to the presence of factor V inhibitors. The patient was successfully treated with transfusion support, immunosuppressive therapy, and continuous renal replacement therapy (CRRT) for fluid management, leading to resolution of symptoms and normalization of coagulation parameters.

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Cite This Study

Yang et al. (Thu,) studied this question.

synapsesocial.com/papers/69c771f08bbfbc51511e20d1 https://doi.org/https://doi.org/10.1186/s12959-026-00857-6

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