Facile Access to Difluoromethylene-Linked Strained Aliphatic Rings from 2-(Difluoromethylene)cyclobutyl Sulfonium Salts (CB-DFAS) and 1.1.1Propellane

Key Points

• The aim is to create difluoromethylene-linked strained aliphatic rings from specific sulfonium salts and propellane.
• Developed a chemodivergent platform for synthesis.
• Used 2-(difluoromethylene)cyclobutyl sulfonium salts and [1.1.1]propellane as starting materials.
• Modulated reaction conditions to achieve different products.
• Produced three unique difluoromethylene-bridged strained scaffolds.
• Demonstrated the versatility of the reaction platform.
• Indicated potential for further applications in synthetic chemistry.