ABSTRACT A direct and efficient acetylaminoselenylation reaction of unactivated alkenes is reported herein, utilizing acetonitrile as the nucleophile through a copper‐catalyzed redox process. This transformation features a broad substrate scope, excellent regioselectivity, and affords β ‐acetamido selenide derivatives in moderate to high yields. Notably, the method employs cost‐effective copper catalysts and mild reaction conditions, addressing the limitations of existing synthetic routes for β ‐acetamido selenides. These attributes make it a practical platform for constructing molecular scaffolds with potential biological and pharmaceutical relevance.
Wang et al. (Sat,) studied this question.