Reply to Dolu, K.O. Comment on “Yorulmaz et al. Enhancing the Prediction of Inborn Errors of Immunity: Integrating Jeffrey Modell Foundation Criteria with Clinical Variables Using Machine Learning. Children 2025, 12, 1259”

Key Points

• The response addresses enhancements in predicting inborn errors of immunity through machine learning integration with clinical criteria.
• Engagement with existing commentary on predictive models
• Analysis of previous findings regarding the integration of machine learning
• Consideration of clinical variables in prediction accuracy
• Reinforcement of the importance of combining machine learning with established criteria
• Validation of enhanced predictive capabilities for inborn errors of immunity
• Discussion of potential impacts on clinical practice