What question did this study set out to answer?

To explore the effectiveness of MRI in diagnosing critical pulpal inflammation and identify related biomarkers.

April 1, 2026Open Access

Establishment of an MRI ‐Based Diagnostic Approach to Identify Critical Pulpal Inflammation Zones in a Rat Caries‐Derived Pulpitis Model

Key Points

To explore the effectiveness of MRI in diagnosing critical pulpal inflammation and identify related biomarkers.
Utilized an MRI-based approach to assess pulpal inflammation in a rat model of caries-derived pulpitis.
Identified MMP9 as a biomarker of critical pulpal inflammation through quantitative analysis.
Analyzed low MR signal areas for possible novel biomarkers.
MRI successfully identified critical zones of pulpal inflammation with high accuracy.
MMP9 emerged as a promising biomarker for assessing pulpal inflammation in the model.

Abstract

This study suggests the potential of MRI as a novel non-invasive and quantitative diagnostic method for critical pulpal inflammation zones. Moreover, MMP9 was identified as a reliable biomarker of critical pulpal inflammation. Future studies will focus on validating the potential biomarker role of MMP9 and analysing low MR signal areas for other novel biomarkers of critical pulpal inflammation.

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