Phosphine-catalyzed sequential 4+ /2+3 annulation of o -amino arylaldimines with Morita–Baylis–Hillman (MBH) carbonates

Key Points

• This research aims to develop an efficient method for sequential annulation reactions using phosphine catalysis.
• Utilized phosphine as a catalyst for the reaction
• Performed sequential [4+1]/[2+3] annulation
• Involved o-amino arylaldimines and Morita–Baylis–Hillman carbonates
• Generated hexahydropyrrolo[3,2-b]indoles with multiple stereogenic centers
• Successfully synthesized a variety of hexahydropyrrolo[3,2-b]indoles
• Obtained compounds featuring three consecutive stereogenic centers
• Highlighted the efficiency of the phosphine-catalyzed process in producing complex structures