Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice | Synapse
April 1, 2026Open Access
Preoperative Beta‐Hydroxy‐Beta‐Methyl‐Butyrate Supplementation Reduces Mitochondrial Dynamics Proteins and Preserves Hepatic Mitochondrial Function After Partial Hepatectomy in Mice
Key Points
To investigate the effects of preoperative HMB supplementation on hepatic mitochondrial function after partial hepatectomy.
Conducted a preoperative intervention with HMB supplementation in mice.
Performed partial hepatectomy to assess liver recovery.
Measured mitochondrial dynamics proteins and function post-surgery.
HMB supplementation reduced levels of mitochondrial dynamics proteins.
Preserved mitochondrial capacity following partial hepatectomy.
Abstract
Our findings suggest that preoperative HMB supplementation preserves hepatic mitochondrial capacity after PHx.