Spatial heterogeneity of intestinal fibrosis in CD limits the diagnostic accuracy of conventional whole-region MRE analysis. Fibrosis is more severe in the mesenteric than the antimesenteric border, with subregional MRE analysis outperforming whole-circle analysis in fibrosis detection. Baseline mesenteric border fibrosis severity most strongly predicts CD progression, necessitating subregionalization for outcome prediction and management.
Wu et al. (Mon,) studied this question.