Higher estimated pulse wave velocity was associated with a 32% increased risk of incident cognitive impairment per standard deviation increase in adults with diabetes (HR 1.32).
Cohort (n=893)
Yes
Does higher estimated pulse wave velocity predict incident cognitive impairment in adults with diabetes?
Estimated pulse wave velocity is a modest, accessible surrogate for arterial stiffness that predicts cognitive impairment in diabetic adults, though its predictive accuracy is limited at the individual level.
Effect estimate: HR 1.32 (95% CI 1.10-1.58)
p-value: p=0.004
Diabetes mellitus (DM) is a major modifiable risk factor for dementia, yet cost-effective, scalable methods for early identification of cognitively at-risk individuals remain limited. To evaluate the predictive value of estimated pulse wave velocity (ePWV), alone and in combination with metabolic markers, for incident cognitive impairment in adults with diabetes. We analyzed 893 adults with DM from the China Health and Retirement Longitudinal Study (CHARLS, 2011–2020). ePWV was derived from age and routine blood pressure, and evaluated alone and in interaction with metabolic markers—triglyceride–glucose (TyG) index and HbA1c—for prediction of cognition impairment over nine years. Analyses included Cox regression, K‑means clustering, Kaplan–Meier survival, generalized estimating equations (GEE), ROC curves, and sensitivity tests, including propensity score matching. Higher ePWV was linked to cognitive impairment in unadjusted and partially adjusted Cox models (hazard ratio (HR) per standard deviation (SD): 1.32; 95% confidence index (CI) 1.10–1.58), but the highest quartile lost statistical significance after full biochemical and clinical adjustment. K‑means clustering and unadjusted survival analyses showed significant group differences, which were attenuated after adjustment. GEE analyses confirmed this pattern across repeated measures. Sensitivity analyses indicated robustness to unmeasured confounding. ROC AUCs ranged 0.61–0.69, reflecting limited discrimination. ePWV demonstrated modest, adjustment‑sensitive associations with cognitive impairment in DM and limited predictive accuracy. In this context, ePWV is better suited for identifying population‑level vascular risk patterns rather than for precise individual prognostication. Combining ePWV with broader vascular, metabolic, and cognitive markers may improve predictive performance.
Kong et al. (Mon,) conducted a cohort in Diabetes mellitus (n=893). Estimated pulse wave velocity (ePWV) vs. Lower ePWV was evaluated on Incident cognitive impairment (HR 1.32, 95% CI 1.10-1.58, p=0.004). Higher estimated pulse wave velocity was associated with a 32% increased risk of incident cognitive impairment per standard deviation increase in adults with diabetes (HR 1.32).