Coreopsis tinctoria Nutt. polyphenols attenuate acrylamide‐induced cerebral injury via dual modulation of Nrf2/ HO ‐1 and MAPK pathways

Key Points

• The aim is to explore how polyphenols from Coreopsis tinctoria can protect against cerebral injury caused by acrylamide.
• Evaluation of the effects of CTNP on acrylamide-induced neurotoxicity.
• Assessment of Nrf2/HO-1 antioxidant and MAPK anti-inflammatory pathways.
• Identification of diet-derived bioactives with protective properties.
• CTNP significantly reduces acrylamide-induced neural damage.
• Observations suggest activation of Nrf2/HO-1 and modulation of MAPK pathways.
• Indications of CTNP's potential as a functional food component for preventing neurotoxicity.