What question did this study set out to answer?

The aim is to investigate how oleanolic acid affects ovarian aging and its mechanisms in laying hens.

April 3, 2026Open Access

Oleanolic Acid Attenuates Ovarian Aging in Laying Hens via Inhibition of the cGAS–STING Pathway

FHFeng-Jie HuZhejiang Center for Disease Control and Prevention CZChen ZhaoZhejiang Center for Disease Control and Prevention MXMing-Hui XiaoZhejiang Center for Disease Control and Prevention

Key Points

The aim is to investigate how oleanolic acid affects ovarian aging and its mechanisms in laying hens.
Examined the molecular effects of oleanolic acid on ovarian aging in laying hens.
Monitored changes in granulosa cell apoptosis and the expression of SASP factors.
Assessed improvements in egg production and ovarian architecture with prolonged OA supplementation.
Oleanolic acid significantly reduced granulosa cell apoptosis and SASP factor expression.
Supplementation led to markedly improved egg production in aged hens.
OA delayed ovarian functional decline and preserved ovarian structure.

Abstract

Ovarian aging is a critical contributor to the decline in reproductive performance in poultry, characterized by diminished folliculogenesis and elevated follicular atresia.Recent studies have identified chronic inflammation and cellular senescence as key drivers of this degenerative process.In this study, we examined the effects of oleanolic acid (OA), a natural pentacyclic triterpenoid, on ovarian aging in laying hens and elucidated its molecular mechanisms of action.Our findings revealed that OA significantly suppressed the expression of senescence-associated secretory phenotype (SASP) factors and reduced granulosa cell apoptosis.Prolonged OA supplementation markedly improved egg production in aged hens, preserved ovarian architecture, and delayed ovarian functional decline.Mechanistically, OA was found to suppress STING activation and its downstream signaling, thereby attenuating cGAS-STING-mediated

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