Naltrexone as Pre-exposure Prophylaxis for Unintentional Opioid Overdose in Stimulant Use Disorder: A Case Report

Key Points

• The aim is to explore the potential of naltrexone as a harm-reduction method for preventing opioid overdose in individuals with stimulant use disorder.
• Case report describing the use of oral naltrexone
• Assessment of the individual's substance use profile
• Monitoring for opioid-related morbidity and mortality
• Oral naltrexone demonstrated potential for reducing opioid overdose incidence
• Observed decrease in opioid-related morbidity in the individual
• Need for further research on implementation and efficacy