Sleep architecture and self-reported sleep quality are associated with Alzheimer’s disease biomarkers in older adults without dementia

Key Points

• This research aims to examine the relationship between sleep architecture, self-reported sleep quality, and Alzheimer's disease biomarkers in older adults without dementia.
• Measured REM sleep architecture using ambulatory EEG.
• Evaluated plasma amyloid profiles in participants.
• Assessed subjective sleep quality through self-reports.
• Greater REM sleep correlated with a more favorable plasma amyloid profile.
• Associations between subjective sleep quality and plasma biomarkers were nominal.
• Findings indicate sensitivity of REM sleep architecture to amyloid-related changes.