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This research aims to develop a model linking dendritic dynamics and cytoskeletal states to associative memory processes.

April 4, 2026Open Access

A Cytoskeletal-Dendritic Key-Lock Model of Associative Memory

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Key Points

This research aims to develop a model linking dendritic dynamics and cytoskeletal states to associative memory processes.
Proposed a key-lock model combining dendritic and cytoskeletal dynamics.
Synthesize existing evidence from various neurobiological studies.
Developed a falsifiable framework with experimental predictions.
Identified the role of fast dendritic dynamics in immediate memory access.
Showed that slower cytoskeletal states affect memory stabilization and retrieval.
Predicted the influence of microtubule and Tau regulation on memory processes.

Abstract

This preprint proposes a cytoskeletal-dendritic key-lock model of associative memory in which fast dendritic and spine dynamics govern immediate access to encoding and recall, while slower cytoskeletal and structural states bias which branches remain available for stabilization, linking, and later retrieval. The paper synthesizes evidence from active dendrites, spine biophysics, microtubule and Tau regulation, synaptic tagging and capture, local translation, and engram research into a falsifiable two-timescale framework with experimental predictions.

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Authors

Robin Langell

Kemakta Konsult

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Kemakta Konsult

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A Cytoskeletal-Dendritic Key-Lock Model of Associative Memory

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Abstract

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