Real-world Clinical and Diagnostic Features of Patients With Isolated Anti-SSB Antibodies Compared With Those With Combined Anti-SSA and Anti-SSB Antibodies

Key Points

• The aim is to evaluate the clinical significance of isolated anti-SSB antibodies compared to combined anti-SSA and anti-SSB antibodies.
• Comparison of clinical features between patients with isolated anti-SSB and those with combined antibodies.
• Assessment of associations with Sjögren disease, systemic lupus erythematosus (SLE), and rheumatoid arthritis (RA).
• Isolated anti-SSB positivity is linked to a significantly lower likelihood of Sjögren disease.
• Patients with isolated anti-SSB antibodies show less association with SLE and RA.
• Isolated anti-SSB may be clinically insignificant for many patients.