UBE2I Alleviates Pyroptosis in Coronary Heart Disease by Promoting the SUMOylation and Degradation of NLRP3

Key Points

• The aim is to explore UBE2I's effects on NLRP3 degradation and pyroptosis in coronary heart disease.
• Investigated UBE2I’s role in the SUMOylation pathway
• Examined the relationship between UBE2I and NLRP3 degradation
• Assessed pyroptosis levels in coronary heart disease models
• UBE2I enhances the degradation of NLRP3 via SUMOylation
• Reduction of pyroptosis was observed in correlation with increased UBE2I activity
• UBE2I is suggested as a potential therapeutic target for coronary heart disease