Abstract Previously, we identified that BAZ1A and SMARCA5 were significantly downregulated in in African American (AA) prostate cancer (PCa), and that BAZ1A altered vitamin D receptor (VDR)-dependent transcriptional sensitivity. SMARCA5 is the ATPase core of different chromatin remodeling complexes, including WICH that promotes accessible chromatin at developmental enhancers, and NoRC, which mediated repression of rDNA transcription and contributes to nucleolar stress pathways. In the current study we tested how ancestry shaped the composition and impact of the SMARCA5 complex. Integrative ATAC-Seq, and H3K27ac and AR CUT Part 1 (Regular Abstracts); 2026 Apr 17-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2026;86(7 Suppl):Abstract nr 3229.
Hussain et al. (Fri,) studied this question.